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Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease

Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighbor...

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Bibliographic Details
Main Author: D'Andrea, Michael R. (Author)
Format: Book
Language:English
Published: Amsterdam Elsevier Academic Press [2015]
Subjects:
Alzheimer's disease > Pathogenesis
Alzheimer Disease > etiology
Alzheimer Disease > physiopathology
Neurons > pathology
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Table of Contents:
  • Alzheimer's disease today
  • Seeds of a new perspective
  • Introducing the "inside-out" hypothesis
  • Addressing technical concerns
  • The good intentions of formic acid
  • Connecting MAP-2 and cell lysis
  • Classifying plaques
  • When is a star like a plaque
  • The inflammation cascade-- Innocent A[beta]42
  • The Alpha 7 nicotinic acetylcholine receptor
  • Immunoglobulin: another perpetrator
  • Add AD to the list of autoimmune diseases - - The BBB and BRB in AD
  • "Inside-out" in the field
  • Alzheimer's disease tomorrow

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