Drug discovery and development technology in transition
The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historica...
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Edinburgh, Scotland
Elsevier
2013
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| Edition: | 2nd ed. |
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| Call Number : | med QV 744 .D78 2013 |
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| 060 | 1 | 0 | |a QV 744 |b .D78 2013 |
| 090 | |a med QV 744 |b .D78 2013 | ||
| 245 | 1 | |a Drug discovery and development |b technology in transition |c edited by R.G. Hill, H.P. Rang ; foreword by Patrick Vallance. | |
| 250 | |a 2nd ed. | ||
| 260 | |a Edinburgh, Scotland |b Elsevier |c 2013 | ||
| 300 | |a xiv, 345 p. |b ill. |c 25 cm. | ||
| 504 | |a Includes bibliographical references and index | ||
| 505 | |a The development of the pharmaceutical industry / H.P. Rang -- The nature of disease and the purpose of therapy / H.P. Rang, R.G. Hill -- Therapeutic modalities / H.P. Rang, H. LeVine, R.G. Hill -- The drug discovery process : general principles and some case histories / H.P. Rang, R.G. Hill -- Choosing the project / H.P. Rang, R.G. Hill -- Choosing the target / H.P. Rang, R.G. Hill -- The role of information, bioinformatics and genomics / B. Robson, R. McBurney -- High-throughput screening / D. Cronk -- The role of medicinal chemistry in the drug discovery process / P. Beswick, A. Naylor -- DMPK optimization strategy in drug discovery / P.G. Ballard ... [et al.] -- Pharmacology : its role in drug discovery / H.P. Rang -- Biopharmaceuticals / H. LeVine -- Scaffolds: small globular proteins as antibody substitutes / D. Grabulovski, J. Bertschinger -- Drug development : introduction / H.P. Rang, R.G. Hill -- Assessing drug safety / H.P. Rang, R.G. Hill -- Pharmaceutical development / T. Lundqvist, S. Bredenberg -- Clinical development: present and future / C. Keywood -- Clinical imaging in drug development / P.M. Matthews -- Intellectual property in drug discovery and development / P. Grubb -- Regulatory affairs / I. Hogglof, Holmgren -- Marketing the drug? / V.L. Lawton -- Drug discovery and development : facts and figures / H.P. Rang, R.G. Hill. | ||
| 520 | |a The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. | ||
| 592 | |a 00003880/13 |b 3/9/2013 |c RM 225.08 |h Areesh | ||
| 650 | 1 | 2 | |a Drug Discovery |
| 650 | 2 | 2 | |a Technology, Pharmaceutical |
| 650 | 2 | 2 | |a Biopharmaceutics |
| 650 | 0 | |a Drugs |x Design | |
| 650 | 0 | |a Drug development | |
| 999 | |a vtls000049751 |c 49104 |d 49104 | ||