Guber is a surname. Notable people with the surname include:
*Jasminka Guber (born 1985), Bosnian middle-distance runner
*Lee Guber (1920–1988), American theater impresario
*Peter Guber (born 1942), American business executive, entrepreneur, educator, and author
*Rebeca Guber (1926–2020), Argentine mathematician, university professor, textbook author
*Rivka Guber (1902–1981), Israeli social worker and pioneer, recipient of the Israel Prize
*Susan Guber (born 1938), American politician in the state of Florida
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